Identification and Genetic Mapping of Genes for Hereditary Breast Cancer and Ovarian Cancer in Families Unlinked to BRCA1.
Annual rept. 22 Aug 94-21 Aug 95,
UTAH UNIV SALT LAKE CITY
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Due to the successful completion of most of the goals of our original proposal through the localization of a second major breast cancer susceptibility locus, BRCA2, on chromosome 13q Wooster et al., 1994, we have expanded the scope of the proposal in a number of significant ways. We now plan to use a set of existing and newly ascertained breast cancer families likely due to BRCA2 to better understand the cancer risks conferred by the gene and how other risk factors may interact with BRCA2 in determining risk. We also have begun studies designed to examine haplotype sharing for markers in the BRCA2 region in order to further localize the BRCA2 locus and eventually identify families which may derive from a common ancestral mutation. To this end we have developed 8 polymorphic genetic markers in the BRCA2 region preliminary data suggest that there will be many distinct mutations in BRCA2. Based on penetrance analysis of two large ERCA2-linked families, BRCA2 carriers have an estimated risk for female breast cancer of 60 by age 50 and 80 by age 70, and a risk of male breast cancer by age 70 of 6.
- Anatomy and Physiology
- Genetic Engineering and Molecular Biology