Accession Number:

ADA300589

Title:

Role of the Int-3 Oncogene in Mammary Gland Development and Tumorigenesis.

Descriptive Note:

Annual rept. 15 Aug 94-14 Aug 95,

Corporate Author:

COLUMBIA UNIV HEALTH SCIENCES NEW YORK

Report Date:

1995-09-12

Pagination or Media Count:

21.0

Abstract:

Mutational activation of the murine int-3 oncogene can contribute to mammary gland tumorigenesis. Evidence suggests that int-3 regulates the morphogenesis and functional differentiation of the mouse mammary gland. The proposed research investigates the role of int-3 proteins in the normal physiology of breast development and the biochemical properties critical for int-3 transforming activity.

Subject Categories:

  • Biology
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE