Final Technical Report for Contract N00014-91-J-1764 (Columbia College).
Final technical rept.,
COLUMBIA COLL CHICAGO IL
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This study describes hippocampal participation in classical conditioning in terms of a multilayer network that portrays stimulus configuration. The network a describes behavior in real time, b incorporates a layer of hidden units positioned between input and output units, c includes inputs that are connected to the output directly as well as indirectly through the hidden-unit layer, and d employs a biologically plausible backpropagation procedure to train the hidden-unit layer. The model correctly describes the effect of hippocampal and cortical lesions in the following paradigms 1 acquisition of delay and trace conditioning, 2 extinction, 3 acquisition-extinction series of delay conditioning, 4 blocking, 5 overshadowing, 6 discrimination acquisition, 7 discrimination reversal, 8 feature-positive discrimination, 9 conditioned inhibition, 10 negative patterning, 11 positive patterning, and 12 generalization. Some of these results might be extended to the description of anterograde amnesia in human patients.
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