Cell-Matrix Interactions in Breast Cancer Cells.
Annual rept. 15 Aug 94-14 Aug 95,
NORTHWESTERN UNIV EVANSTON IL
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During the report period we have shown that breast epithelial cells attach to connective tissue via specialized matrix connectors called hemidesmosomes. The latter are lost, as are many of their components, in invasive breast tumor cells. Primary breast epithelial cells assemble hemidesmosomes in vitro. The assembly of hemidesmosomes in such cells is enhanced when they. are maintained on matrix secreted by the breast line MCFlOa. Our results emphasize the importance of matrix components in assembly of hemidesmosomes.
- Anatomy and Physiology