The Role of Cyclin Dl Overexpression in Breast Cancer Progression
Annual rept. 15 Jul 1994-14 Jul 1995
SOUTHWEST TEXAS STATE UNIV SAN MARCOS DEPT OF PHYSICS
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The purpose of this grant is to examine the role of the cyclin DI gene, and related genes, in multistage breast carcinogenesis. These studies may provide new biomarkers and suggest novel strategies for the prevention and treatment of breast cancer. During the past year two studies were completed. The first, which is in press in Cardiogenesis indicates that carcinogen-induced rat breast tumors display dysregulation in the expression of cyclins Di and E. Since similar changes are seen in human breast cancers, the rat model may be useful for studying the role of dysregulated expression of these cyclin genes in breast cancer progression and prevention. The second study, which was recently published in Oncogene, indicates that overexpression of cyclin Di in human mammary cells can inhibit rather than stimulate cell growth. The underlying mechanisms and the implications of these findings are the subjects of current studies.
- Medicine and Medical Research
- Anatomy and Physiology