A Role for the NF-kB/Rel Transcription Factors in Human Breast Cancer.
Annual rept. 1 Jul 94-30 Jun 95,
NORTH CAROLINA UNIV AT CHAPEL HILL
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Human breast cancer is characterized by the inappropriate expression of growth factors, kinases and possibly certain transcription factors. Our project focuses on the potential role of a family of transcription factors, the NF-kBRel family, in human breast cancer. Additionally the project will analyze a role for the so-called VNTR elements in the hereditary susceptibility of women to breast cancer and on a role for estrogen in modulating cell growth of human breast cancers. We have found that approximately 35 of human breast cancers overexpress an important member of the NF-kB family the p65 or RelA factor. Present efforts are aimed at understanding a role for this overexpression and at determining the type of tumor that is associated with this overexpression. Additionally, we have described an interesting new function of mutantoncogenic forms of the tumor suppressor p53. Our analysis of VNTR elements has shown that bind to the important transcription factor AP-1. Future experiments are aimed at understanding a functional role for this binding to a DNA element that is associated with-human breast cancer. Additionally we have found that a constitutive form of NF-kB also binds these important elements.
- Medicine and Medical Research