Accession Number:

ADA297167

Title:

Mouse Models of the Neu Ligand Interaction with its Receptor in Mammary Gland Tumorigenesis and Development.

Descriptive Note:

Annual rept. 1 Jun 94-31 May 95,

Corporate Author:

HARVARD COLL CAMBRIDGE MA

Personal Author(s):

Report Date:

1995-06-23

Pagination or Media Count:

10.0

Abstract:

Recently, a family of stimulatory ligands for the EGFerbB family of receptor tyrosine kinases has been described. This family includes Neu differentiation factor NDF, heregulin HRG, acetylcholine receptor inducing activity ARIA, and the glial growth factors GGFs. This family of ligands, known collectively as the neuregulins, is comprised of alternatively spliced isoforms of a common gene. Interaction of the products of this gene with heterodimers andor homodimers of the erbB receptors leads to their auto and transphosphorylation and subsequent interaction with SH-2 proteins including phospholipase C-y PLC-y, the p85 subunit of posphotidylinositol 3-kinase PI-3 K, and the GTFase activating protein of ras ras-GAP.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE