The Effect of Inhaled Nitric Oxide on Smoke Inhalation Injury in an Ovine Model.
ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX
Pagination or Media Count:
Smoke inhalation is a significant comorbid factor in thermal trauma. The effect of inhaled nitric oxide NO on smoke inhalation injury was evaluated in an ovine model. Following smoke exposure, group 1 animals n 9 spontaneously breathed room air, and group 2 animals n 8 breathed 20 parts per million of NO in air for 48 hours. Cardiopulmonary variables and blood gases were serially measured bronchoalveolar lavage BAL was performed and wet-to-dry lung weight ratios WID determined at 48 hours. Pulmonary vasoconstriction following smoke inhalation was significantly attenuated by inhaled NO p 0.05, which exerted no apparent effect on the systemic circulation. In group 2, the serial decline in pulmonary oxygenation was less than in group 1, consistent with a smaller physiologic shunt p 0.05. There were no significant differences in WID, lung compliance, BAL fluid analysis results, or histologic evaluation findings between the two groups. These results suggest that inhaled NO exerted beneficial effects on pulmonary arterial hypertension and oxygenation following smoke inhalation without apparent amelioration of airway inflammation.
- Anatomy and Physiology