Accession Number:

ADA295869

Title:

Pyridostigmine Synergistic Toxicity Study.

Descriptive Note:

Final rept. Apr 94-May 95,

Corporate Author:

ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE (PROVISIONAL) ABERDEEN PROVING GROUND MD

Personal Author(s):

• McCain, Wilfred C.

Report Date:

1995-05-31

Pagination or Media Count:

17.0

Abstract:

This study investigated the lethal interaction of pyridostigmine bromide PB, permethrin, and DEEr when given to adult male rats by gavage. The study was separated into two phases. The first Phase I determined the acute oral lethal dose-response relationship of each compound with the vehicle, propylene glycol. The second Phase II was divided into two portions. One portion positive control was a dose-response study using probit units obtained from phase I LD 16. 30, 50, 70, and S4. Dosage solutions for the second interaction portion of phase II contained the calculated LDl6 additive l,D16 of two compounds while the concentration of the third compound was varied.

Descriptors:

• *TOXICITY
• *PYRIDOSTIGMINE BROMIDE
• CONTROL
• EXPOSURE(GENERAL)
• RATS
• INTERACTIONS
• SOLUTIONS(GENERAL)
• DOSAGE
• LEVEL(QUANTITY)
• ADDITIVES
• HUMAN BODY
• LETHALITY
• MALES
• VALUE
• EXPOSURE(PHYSIOLOGY)
• RESPONSE(BIOLOGY)
• ADULTS
• SYNERGISM
• PYRIDINES
• DEER
• PROPYLENE GLYCOL

Subject Categories:

• Toxicology
• Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE