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Blood Vessel Formation during Wound Healing.
Final rept. 16 Jan 91-16 Jan 95,
TUFTS UNIV BOSTON MA
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This report summarizes a series of studies undertaken to determine if angiogenic molecules isolated from normal tissues and wound fluid could accelerate wound repair. Angiogenesis new blood vessel formation is a critical component of many normal and pathologic processes, including wound healing, thus leading to the hypothesis that it angiogenesis during wound repair was increased, then the wound would heal faster. Our first set of experiments completed the purification of the major lipid angiogenic molecule secreted by differentiating adipocytes, 1-butyryl-glycerol. We also determined that adipocytes secrete Vascular Endothelial Growth Factor, a pep tide which specifically stimulates endothelial cell proliferation and. migration in cell culture, and stimulates angiogenesis in vivo. Synergy between the angiogenic activity of 1-butyryl-glycerol and prostanoids was found, suggesting that multiple signals may be necessary to modulate the angiogenic response in physiologic or pathophysiologic settings. When 1-butyryl-glycerol was tested in a diabetic rat model for wound healing, it was able to significantly accelerate the rate of wound healing in 2 out of 5 experiments. While the lack of reproducibility needs to be resolved, the very positive nature of some of the experiments suggests that 1-butyryl-glycerol may possess clinically useful wound healing capacity.
APPROVED FOR PUBLIC RELEASE