The Fibroblast Response to Anoxia: A Potential Direct Role in Wound Healing.
Final rept. 1 May 91-1 Nov 94,
ROSWELL PARK CANCER INST BUFFALO NY
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Cellular anoxia constitutes an environmental stimulus experienced within early stage healing wounds. Anoxia has effects on fibroblasts which make important contributions to regulating the progressive events of wound healing. These effects are mediated through specific gene induction, resulting in activation of a cellular program including enhanced glycolysis, protease secretion, endonuclease production, and expression of an angiogenesis factor. In a delayed response, fibroblast contractile processes activate at a time appropriate for wound contraction. The anoxic fibroblast response is constitutively activated in a large fraction of malignancies, where it contributes to invasiveness and genomic instability.
- Anatomy and Physiology
- Stress Physiology
- Medicine and Medical Research