Accession Number:

ADA291170

Title:

Molecular Probes of Gating and Open Channel Conformational Transitions of Mechanosensitive Ion Channels.

Descriptive Note:

Final rept.,

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1994-11-14

Pagination or Media Count:

7.0

Abstract:

The objective of this project was to elucidate the molecular mechanisms which control the gating behavior and ion transport properties of mechanosensitive ion channels in skeletal muscle. The project utilized recordings of single-channel activity to address two general questions 1 How does an absence of the cytoskeletal protein, dystrophin, influence the mechanosensitive gating of single channels 2 What is the mechanism by which positively charged aminoglycoside antibiotics inhibit the flow of current through these channels. jg

Subject Categories:

  • Biology
  • Biochemistry
  • Anatomy and Physiology
  • Physical Chemistry
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE