Decreased Pulmonary Damage in Primates With Inhalation Injury Treated with High-Frequency Ventilation.
ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX
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Smoke inhalation leads to a complex sequence of pulmonary and pathophysiologic events that contribute to a high morbidity and mortality when combined with thermal injury.2 While the volume and composition of the inhaled material clearly influence the severity of the pulmonary manifestations of inhalation injury, other data suggest that the mode of ventilatory support may also affect the severity of the disease process.3 The term high-frequency ventilation HFV describes a group of ventilatory techniques that use low tidal volumes at supraphysiologic respiratory frequencies, When used with appropriate ventilation strategies, HFV can maintain the lung at a given mean volume pressure with less excursions above and below the mean than can be accomplished with conventional mechanical ventilation. This, in theory, should lessen the risk of ventilator-induced lung injury. JMD
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