Research On PGI sub 2 and TXA sub 2 Effects at Times of Hyperbaric Oxygenation of Domestic Rabbits with Acute Cerebral Ischemia Reirrigation Damage,
NATIONAL AIR INTELLIGENCE CENTER WRIGHT-PATTERSON AFB OH
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33 New Zealand white rabbits were taken and randomly divided into a control group, a hyperbaric air group, and a hyperbaric oxyengation HBO group. All were reirrigated types following the creation of acute, incomplete cerebral ischemia. Respective measurements were taken of the overall carotid artery and interior jugular vein blood gases as well as cortical brain tissue homogenate amounts of 6-Keto-PGF1 and TXB2 contained. In conjunction with this, pathological investigations were made. The results were that the amounts of 6-Keto-PGF1 contained for the HBO group were clearly greatly increased P 0.01. TXB2 clearly dropped P 0.05. Blood P02 in the HB0 group clearly went up P 0.0l. Pathological investigations showed that the HBO groups brain tissue damage was relatively light. Conclusion there were clear effects on PGI2 and TXA2 with HBO when there was reirrigation after acute cerebral ischemia in the domestic rabbits. This is possibly one mechanism of HBO therapy for acute cerebral ischemia.
- Medicine and Medical Research
- Anatomy and Physiology