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Insulin-Like Growth Factor-1 Lowers Protein Oxidation in Patients with Thermal Injury,
ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX
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Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. Current nutritional support regimens using high calorie and protein enteral or parenteral solutions do not completely reverse net protein catabolism and have little effect on the accelerated rate of protein breakdown. Attempts to limit catabolism by experimental treatment with growth hormone have been promising under certain conditions. 1,2 The administration of pharmacologic doses of growth hormone to fasting adult humans resulted in a protein sparing effect, but has failed to stimulate protein synthesis in other studies.3 Clinical trials using growth hormone in a variety of catabolic conditions demonstrated that growth hormone was somewhat effective in conserving body proteins.45 However, the most severely ill patients did not improved their nitrogen balance. In addition, growth hormone is an insulin antagonist and may exacerbate stress-induced insulin resistance.
APPROVED FOR PUBLIC RELEASE