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Accession Number:
ADA289460
Title:
Preclinical Toxicology Studies for New Drugs and Vaccines.
Descriptive Note:
Annual rept. 15 Nov 93-14 Nov 94,
Corporate Author:
ILLINOIS UNIV AT CHICAGO CIRCLE
Report Date:
1994-12-14
Pagination or Media Count:
19.0
Abstract:
During the reporting period, Two Week Oral Toxicity Studies of WR2425 11 and WR2694 10 in Rats, In Vitro Mutagenicity Tests of WR2425 11 and WR2694 10, Four Week Oral Toxicity Studies of WR2425 11 and WR2694 10 in Dogs, Thirteen Week Oral Toxicity Studies of WR238603 and WR6026 with a Thirteen Week Recovery Period in Dogs, a Thirteen Week Oral Toxicity Study of WR2694 10 in Rats, and Acute Oral and IP Toxicity Studies of WR2425 11 and WR269410 in Rats were completed and study reports submitted. Revised draft reports were submitted for Thirteen Week Oral Toxicity Studies of WR238605 with a Thirteen Week Recovery Period in dogs and rats. WR242511 and WR269410 were studied in Thirteen Week Oral Toxicity Studies in Rats and a Four Week Oral Toxicity Study in Dogs, and draft reports were submitted. One Week Intramuscular Dose Range-Finding Studies of Co-administered HI-6 Dichioride Monohydrate and Atropine Citrate in dogs and rats were also conducted, and draft reports submitted. Lastly, draft reports were submitted for a Thirteen Week Oral Toxicity Study in Rats, a Dose Range-Finding Developmental Toxicity Study in Rats and a Four Week Oral Toxicity Study in Dogs on WR2425 11. Ampicillin in Rabbits, a Four Week Toxicity Study of WR269410 in Dogs, Dose Range-Finding and Developmental Toxicity Segment II Studies of WR2423 11 in Rabbits, a Developmental Toxicity Segment II Study of WR2425 11 in Rats, Two Week Toxicity Studies of HI6 Dichioride in Dogs and Rats, Dose Range-Finding and Developmental Toxicity Segment II Studies of WR238605 and WR6026 in Rats.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
