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Anti-Idiotype Probes for Toxin Detection.
Final rept. 15 Sep 89-14 Oct 94,
KANSAS STATE UNIV MANHATTAN
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This study was designed to investigate the interaction of staphylococcal enterotoxins and exfoliative toxins with leukocytes and to establish baseline information on the consequences of those interactions. Receptor-ligand interactions were characterized and a new non-MHC class II receptor on the surface of macrophages was discovered. Once these data were at hand, we also prepared an anti-idiotype antibody to class II MHC and have used it to inhibit interaction of toxins with their cognate receptor on macrophage surfaces. These studies have resulted in the publication of 31 manuscripts and 7 published abstracts.
APPROVED FOR PUBLIC RELEASE