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Testing of Experimental Antileishmanial Compounds.
GEORGIA UNIV RESEARCH FOUNDATION INC ATHENS
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Six plant derivatives which were selected for in vivo study because of their in vitro antiLeishimanial activity and low toxicity were studied for activity against Leishmania Leishmania donovani and Leishmania Viannia brazitiensis in hamsters. The time interval between completion of treatment and evaluation of results was extended up to 4-6 weeks to evaluate any possible delayed antiLeishmanial activity by the compounds. None of the compounds studied were active in hamsters against either species of Leishmenia. Extension of time between treatment and evaluation of results did not increase the in vivo activity of any of the compounds studied. None of the compounds studied were toxic based on body weight toss, mortality, or clinical signs.
APPROVED FOR PUBLIC RELEASE