Accession Number:

ADA288431

Title:

Protection Against the Acute and Delayed Toxicities of Mustard and Mustard-Like Compounds.

Descriptive Note:

Midterm rept. 30 Nov 92-4 Jun 94,

Corporate Author:

MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER

Personal Author(s):

• Ludlum, David B.

Report Date:

1994-06-04

Pagination or Media Count:

42.0

Abstract:

We are investigating the hypothesis that modalities which cause a reversible cell cycle arrest will decrease sulfur mustard toxicity by allowing more time for DNA repair before cell division takes place. Both human fibroblasts and NM-1 keratinocytes have been exposed to hypothermic conditions 280C. This temperature arrests the growth of both cell lines, but they recover rapidly on transfer back to 37 deg C. Similarly, exposure to 8 uM ciclopirox olamine produces a readily reversible cell cycle arrest. Experiments are currently in progress to determine the efficacy of these treatments in reducing sulfur mustard cytotoxicity.

Descriptors:

• *TOXICITY
• *FIBROBLASTS
• *MUSTARD AGENTS
• LOW TEMPERATURE
• EXPOSURE(GENERAL)
• TEMPERATURE
• HUMANS
• ARRESTING(PROCESS)
• DEOXYRIBONUCLEIC ACIDS
• REPAIR
• DELAY
• CELL DIVISION
• CYTOTOXINS
• HYPOTHESES
• PATHOLOGY
• SULFUR
• TRANSFER

Subject Categories:

• Toxicology
• Anatomy and Physiology
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE