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Early Detection of Breast Cancer and Recurrence Using Near Infrared Time Resolved Spectrophotometry

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Annual rept. 15 Mar 1993-14 Mar 1994

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The following techniques are employed to measure the optical absorption and scattering factors breast tissue In year 1, a pulse time device in which light at lower power 50 microns W laser diode is employed. The time delay in light propagation from the input to output fiber optic couplers is related to the scattering factor and the measured rate of decay of emerging photons is related to the absorption factor. Phase modulation years 2 and, which is more convenient and rapid, measures the phase shift of a high frequency oscillating light of approximately the same power and wavelength used in the pulse time method. Here, there is direct reading of the time delay which is characteristic of the scattering power when low frequency oscillation is employed. Contrast agents may be used to increase the tumor detection sensitivity. For example, the absorption of porphyrins at 620 nm and indocyanine green at 860 run, afford possibilities to follow the time course of tumor uptake of optical contrast agents. Histopathological confirmation of diagnosis will be obtained and correlated with the optical and MRI results. Both the imaging and optical data obtained from this proposed project will facilitate research on using the optical properties of breast tissue to screen for early stage cancer. Pulse time device, Phase modulation, Contrast agents, Screen for early stage cancer

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  • Medicine and Medical Research
  • Optics

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