Diffusible Driving and Coupling Signals of the Biological Clock
Final rept. 1 Apr 1992-31 Mar 1994
BARNARD COLL NEW YORK
Pagination or Media Count:
The goal of the research has been to determine whether there is evidence of a diffusible coupling signal from the Suprachiasmatic Nucleus. If a diffusible signal is physiologically significant, it has the potential for use as a bioactive agent for exogenous administration. We believe we now have evidence that such a signal exists, and that it can appear in biologically significant amounts in the cerebrospinal fluid. At the present time we are working to complete the most definitive experiments providing such proof. We are also working towards our next goal to establish the experimental conditions for identifying the diffusible signal.
- Anatomy and Physiology