Plasmodium falciparum: Exported Protein-1, A Blood Stage Antigen is Expressed in Liver Stage Parasites.
NAVAL MEDICAL RESEARCH INST BETHESDA MD
Pagination or Media Count:
After inoculation by Anopheles sp. mosquitoes, Plasmodium falciparum sporozoites rapidly make their way to the liver where a single, uninucleate sporozoite develops during a minimum of 5-6 days to a mature liver stage schizont with 1-3 x 10exp 4 uninucleate merozoites. There are no clinical or pathological manifestations associated with this stage of the parasites life cycle, and thus the parasite developing within the liver is an attractive target for vaccine-induced protective immune responses. Infected hepatocytes are the target of protective immune responses induced by immunization with irradiated sporozoites, sporozoites that develop only partially in hepatocytes. However, so-called erythrocytic stage parasite proteins such as the P. falciparum major merozoite protein-1 PfMSP-1 are also expressed in infected hepatocytes. As such, they also could be the targets of cellular or humoral immune responses that prevent the release of infectious merozoites from the liver. The current studies were undertaken to determine whether the erythrocytic stage P. falciparum exported protein 1 Exp-1 is expressed in infected hepatocytes
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