The Study of the Post-Irradiation Syndrome in Man
Annual rept. 1 Jan 1960-31 Jan 1961
MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK
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The object of this investigation has been to study the post irradiation syndrome in humans in as many parameters as possible and to evaluate the effects of low doses of total body irradiation on modification of tumor response. The selection of patients and the dosage schedules were essentially the same as set forth previously in our annual reports to the Department of the Army. The emphasis during the period of this report was on repeated small doses of irradiation. Six courses of total body irradiation were followed in five patients for periods of time from 40 to 80 days. Radiation was delivered with the 2 Mev van de Graaf generator. Three patients received single exposures one received 88 r, one 50 r and a third patient received 50 r total body followed within the week by the onset of a course of irradiation to large portals on the abdomen. During the next 26 days this patient was given a midplane dose of 4000 r. Two patients received fractionated doses of irradiation one received 25 r for five consecutive days the second patient recovered 25 r and received two sham irradiations at weekly intervals thereafter. Nine months later this patient returned and received 30 r x 3 at weekly intervals.