Accession Number:

ADA284195

Title:

Biochemistry and Chemotherapy of Malaria and Leishmaniasis

Descriptive Note:

Annual rept. 2 Nov 1992-1 Nov 1993

Corporate Author:

MASSACHUSETTS UNIV AMHERST

Personal Author(s):

Report Date:

1993-12-06

Pagination or Media Count:

42.0

Abstract:

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to 1 Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., 2 To tests the effect of natural products on Leishmania sp. and to 3 Continue the mode of action studies on the nature of the inhibitory action of arachidonic on DNA polymerase.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE