Accession Number:

ADA282710

Title:

Biological Characterization of HIV-2

Descriptive Note:

Final rept. 28 Sep 1990-27 Sep 1993

Corporate Author:

HARVARD SCHOOL OF PUBLIC HEALTH BOSTON MA

Personal Author(s):

Report Date:

1994-04-03

Pagination or Media Count:

46.0

Abstract:

Our data on the biology of HIV-2 suggest that this virus has a distinct biology from that of its closest relative HIV-1. It was therefore relevant to assess these differences in populations infected with significant rates of both HIV-2 and HIV-1. Senegal is such a West African country, and the studies established there have provided important new information on the natural history and epidemiology of HIV-2. The prolonged incubation period for HIVs in general suggest that much can be learned from the evaluation of infected individuals over time. In this contract we have described differences in the heterosexual transmission, incubation period to disease and epidemic curves of HIV-2 compared to HIV-1. A number of virologic and immunologic differences between these viral infections have been described which may play a role in these different pathogenic potentials and biologics. Our studies conducted to date, have already indicated differences in the above virus-host interactions between HIV-2 and HIV-1. Continued comparative studies contribute to our overall understanding of HIV pathogenesis. Human retroviruses, AIDS, HIV-1, HIV-2, SIV, West Africa, Vaccines, Biology, Biotechnology, RAD I

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE