Accession Number:

ADA282637

Title:

Effects of Normobaric and Hyperbaric Oxygen on Survival, Regional Blood Flow and Tissue Oxygen Tension in Hemorrhagic Shock in Rats.

Descriptive Note:

Final rept. 30 Sep 92-29 Sep 93,

Corporate Author:

CARMEL HOSPITAL HAIFA (ISRAEL)

Personal Author(s):

Report Date:

1993-11-30

Pagination or Media Count:

23.0

Abstract:

This study investigated mechanisms of the hemodynamic effects of oxygen in hemorrhagic shock induced by bleeding 35 of the total blood volume in rats. Hemorrhage induced a marked decrease in mean arterial blood pressure MABP, a 40 decrease in blood flows to the hind quarters, the biceps femoris muscle, and the small bowel, as well as a 62 decrease in superior mesenteric artery SMA flow. This was accompanied by a 73 increase in resistance in the SMA vascular bed. Inhalation of 100 oxygen induced a significant increase of 33 or -3 mmHg in MABP. This was accompanied by a significant increase in vascular resistance in the hind quarters and a concomitant decrease in blood flows in the distal aorta and the biceps femoris muscle. In contrast, oxygen did not change vascular resistance in the SMA bed, and induced a significant increase in blood flow to the SMA and small bowel. Administration of L-Arginine 100 mgkg i.v completely abolished the effects of oxygen on blood pressure and reversed its effects on blood flow and resistance in the hind quarters and biceps femoris muscle.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE