Chemoselective Reactions of a-Aminonitriles.
Final rept. May-Aug 93,
EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD
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A carbocyclic model for 4-anilino-4-cyano-l-benzylpiperidine was used to elucidate the chemistry of the reaction with diisobutylaluminum hydride. Reactions with alkaline hydrogen peroxide, triethyloxonium tetrafluoroborate and boron trifluoroetherate in methanol were studied for possible chemoselectivity for the cyano as opposed to the anilino function. Aminonitriles, DIBAL-H, Lewis acids.
- Organic Chemistry
- Inorganic Chemistry
- Physical Chemistry