Accession Number:

ADA281899

Title:

Prostaglandin E2 Regulation of Chondrocyte Proliferation and Differentiation

Descriptive Note:

Master's thesis

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSONAFB OH

Personal Author(s):

Report Date:

1994-05-01

Pagination or Media Count:

96.0

Abstract:

Endochondral ossification involves the differentiation of chondrocytes, along with the process of extracellular matrix formation and mineralization by these cells. Vitamin D3 is essential to the regulation of endochondral ossification. The chondrocyte response to vitamin D3 is dependent on the level of cell maturation and the particular vitamin D3 metabolite used. Growth zone chondrocytes respond primarily to 1,25-dihydroxy vitamin D3 and resting zone chondrocytes respond primarily to 24, 25-dihydroxy vitamin D3. Prostaglandin E2 production by growth zone and resting zone chondrocytes is regulated by vitamin D metabolites and is believed to be a mediator between these hormones and their final effect on the cells

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE