Accession Number:

ADA281334

Title:

Isolation of a Puumala-Like Virus from Mus musculus Captured in Yugoslavia and Its Association with Severe Hemorrhagic Fever with Renal Syndrome

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Report Date:

1994-01-01

Pagination or Media Count:

4.0

Abstract:

An outbreak of severe hemmorrhagic fever with renal syndrome HFRS occurred in 1988 in Pozarevac, Serbia, Yugoslavia. The disease was diagnosed inm 4 children and 1 adult, and 1 of the children died. Rodents were captured from the same area and virus isolation attempted. A hanta-virus, POZ-M1, was isolated from lung tissues of hantavirus antigen-positive Mus musculus. Serology and restriction enzyme digestion of polymerase chain-amplified segments from the virus showed that it was a strain of Puumala PUU virus, the causative agent of nephropathia epidemica. While Clethrionomys glareolus is the major rodent host for PUU virus, these results suggest that M. musculus may also play an important role in harboring and transmitting PUU-like viruses. The serologic association of this virus with patients with serve HFRS reaffirms that PUU-like viruses may cause severe disease in addition to the generally mild form normally associated with nephropathia epidemica

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE