Accession Number:

ADA281015

Title:

Support for HIV-1 Intervention Therapy

Descriptive Note:

Annual rept. 30 Sep 1992-29 Sep 1993

Corporate Author:

SRA TECHNOLOGIES INC ALEXANDRIA VA

Personal Author(s):

Report Date:

1993-10-01

Pagination or Media Count:

87.0

Abstract:

This contract is intended to provide both research and development support of clinical studies in HIV antiviral chemotherapy, immunotherapy and immunoprophylaxis. The primary objectives of the contract as stipulated in the contract award, are a to develop assays to evaluate the viral and immune responses to anti-retroviral therapy to include neutralization assays and drug susceptibility assays using clinical HIV isolates, b to develop and validate assays that predict or demonstrate disease progression for use in interventional trials with an emphasis on molecular biologic approaches to viral characterization and quantification of viral burden, and c to improve the accuracy, reliability, and cost effectiveness of clinical laboratory tests for all stages of HIV-1 and other retroviral infections. The contractor has incorporated two working groups to develop and optimize the necessary assays in support of these clinical studies and to establish production-level protocols. HIV, Therapy, RAD I, HIV-1.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE