The Chronic Effects on JP-8 Jet Fuel Exposure on the Lungs
Final technical rept. 1 Apr 1991-31 Mar 1994
ARIZONA UNIV HEALTH SCIENCES CENTER TUCSON
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There are four major findings from the three years of work devoted to the effects of chronic JP-8 jet fuel exposure on the lungs and secondary organs. These findings are the following chronic exposure to JP-8 jet fuel alters pulmonary function and lung structures with an acute response with as little as seven days of low dose, approximately 500 mgm3, exposure to JP-8 jet fuel chronic exposure to JP-8 jet fuel increased liver, spleen, and kidney weights compared to controls. Microscopic evaluation of liver sections were normal however, kidney and spleen had histological changes consistent with organic solvent exposure. There is a correlation between JP-8 jet fuel exposure-induced decreases in lung Substance P levels and lung neutral endopeptidase levels. Chronic exposure to JP-8 jet fuel caused a decrease in lung Substance P levels with a corresponding increase in lung neutral endopeptidase levels and, there is a recovery process in the 56 day low dose JP-8 jet fuel-exposed lungs as marked by a return to baseline and longitudinal control 99mTcDTPA values. The 99mTcDTPA data was very consistent with our pathologic findings of very little lung injury in the 56 day low dose JP-8 jet fuel-exposed rats. We speculate that this finding indicates that there is a threshold level of JP-8 jet fuel exposure that the lungs defense mechanisms can tolerate.
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