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Cell Culture and Transplantation of the Suprachiasmatic Circadian Pacemaker
Annual rept. 30 Sep 1992-29 Sep 1993
TORONTO UNIV (ONTARIO) DEPT OF PSYCHOLOGY
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The general aim of the research supported by AFOSR is to understand how circadian rhythms in mammals are generated and controlled. We have used a variety of techniques to ask such questions as 1 How does photic information reach and affect the clock 2 What is the nature of the electrical events in pacemaker cells responsible for the generation and expression of rhythmicity 3 What are the biochemical components of the pacemaker system In particular, we have used the tau period mutation in the golden hamster, to pursue experiments designed to eventually identify mammalian circadian pacemaker cells.
APPROVED FOR PUBLIC RELEASE