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Accession Number:
ADA280896
Title:
Connective Tissue Breakdown and Bone Morphology Change Following Increased Intensity Exercise
Descriptive Note:
Final rept. 1987-1991
Corporate Author:
NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA
Report Date:
1991-01-01
Pagination or Media Count:
17.0
Abstract:
Two plasma indicators of connective tissue CT degradation have been identified in previous work. One of the these, hydroxyproline OHP, is a widely accepted measure of CT turnover the other, hydroxylysylpyridinoline HP, has only recently been isolated in plasma. In this study, responses of OHP and HP are compared to bone morphology changes associated with a 9-week period of increased intensity aerobic exercise. Bone morphology was measured as tibial bone mineral density BMD from dual photon absorptiometry DPA, and tibial cross-sectional area XAREA from quantitative computed tomography QCT. Nine local club runners TGRP mean age 36.6 yrs, distance 22.9 kmwk, pace 3.30 m sec ran their normal program for a 3-week baseline period. Their pace was increased 4 distance unchanged for a 9-week period. Ten university staff personnel whose training remained stable for 9 weeks served as controls. OHP, HP, BMD, and XAREA were measured prior to T1 and following T2 the 9-week period. Repeated measures ANOVA revealed significant group by time interactions for OHP p0.03, HP P0.001, and BMD p0.02. OHP and HP increased and BMD decreased significantly for the TGRP at T2. XAREA was unchanged. A modest, but significant, Spearman Correlation -0.44, p0.03 was found between residuals approached significance -0.37, p0.06. It was concluded that1 bone mineral density adjustments to increased intensity were not complete after 9 weeks, 2 increased intensity exercise at a 4 rate does not alter tibial XAREA, and 3 HP appears to be a better indicator of connective tissue degradation tan is OHP
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
