Accession Number:

ADA280359

Title:

Two-Dimensional Protein Pattern Recognition in Chemical Toxicity

Descriptive Note:

Annual rept. 1 Apr 1993-30 Mar 1994

Corporate Author:

INDIANA UNIV-PURDUE UNIV AT COLUMBUS DEPT OF BIOLOGY

Personal Author(s):

• Witzmann, Frank A.

Report Date:

1994-04-20

Pagination or Media Count:

47.0

Abstract:

This report summarizes the progress made in the development of a two-dim pro database for toxicity screening and mechanistic determination. Various chemically distinct peroxisome proliferators were compared with regard to their effect on the 2 protein pattern of various target tissues in the rodent. Protein alterations, novel identifications, and future directions are described. Rat liver, Rat kidney, Rat testis, Perfluorcarboxylic acid peroxisome proliferator, 2D Protein electrophoresis, Image analysis, Protein sequence, Pattern Recognition.

Descriptors:

• *TOXICITY
• *LIVER
• *ELECTROPHORESIS
• DATA BASES
• RATS
• ENZYMES
• TARGETS
• IMAGES
• RECOGNITION
• DETERMINATION
• FATTY ACIDS
• KIDNEYS
• ACIDS
• RODENTS
• PATTERN RECOGNITION
• PATTERNS
• SEQUENCES
• PROTEINS
• CHEMICALS
• TWO DIMENSIONAL

Subject Categories:

• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE