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Two-Dimensional Protein Pattern Recognition in Chemical Toxicity
Annual rept. 1 Apr 1993-30 Mar 1994
INDIANA UNIV-PURDUE UNIV AT COLUMBUS DEPT OF BIOLOGY
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This report summarizes the progress made in the development of a two-dim pro database for toxicity screening and mechanistic determination. Various chemically distinct peroxisome proliferators were compared with regard to their effect on the 2 protein pattern of various target tissues in the rodent. Protein alterations, novel identifications, and future directions are described. Rat liver, Rat kidney, Rat testis, Perfluorcarboxylic acid peroxisome proliferator, 2D Protein electrophoresis, Image analysis, Protein sequence, Pattern Recognition.
APPROVED FOR PUBLIC RELEASE