Accession Number:

ADA279892

Title:

New Chiral Pyrimidino-Crown Ether Ligands.

Descriptive Note:

Technical rept.,

Corporate Author:

BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY

Personal Author(s):

• Redd, J. T.
• Bradshaw, Jerald S.
• Huszthy, Peter
• Izatt, Reed M.

Report Date:

1994-05-11

Pagination or Media Count:

11.0

Abstract:

Two new chiral macrocyclic ligands containing the pyrimidine subcyclic unit Figure 1 have been prepared. Chiral dimethyl-substituted pyrimidino-crown 1 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate 3 and chiral dimethyl-substituted tetraethylene glycol. Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate 4 with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 2. Starting 4-methoxy-5-methyl-2, 6-pyrimidinedimethanol 11 was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.

Descriptors:

• *LIGANDS
• *PYRIMIDINES
• METHYL RADICALS
• AMINES
• RECOGNITION
• ETHYL RADICALS
• CARBOXYL RADICALS
• ETHYLENE GLYCOL
• MOLECULAR PROPERTIES
• ETHERS
• METHANOLS

Subject Categories:

• Inorganic Chemistry
• Organic Chemistry
• Physical Chemistry
• Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE