Accession Number:
ADA279892
Title:
New Chiral Pyrimidino-Crown Ether Ligands.
Descriptive Note:
Technical rept.,
Corporate Author:
BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY
Personal Author(s):
Report Date:
1994-05-11
Pagination or Media Count:
11.0
Abstract:
Two new chiral macrocyclic ligands containing the pyrimidine subcyclic unit Figure 1 have been prepared. Chiral dimethyl-substituted pyrimidino-crown 1 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate 3 and chiral dimethyl-substituted tetraethylene glycol. Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate 4 with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 2. Starting 4-methoxy-5-methyl-2, 6-pyrimidinedimethanol 11 was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.
Descriptors:
Subject Categories:
- Inorganic Chemistry
- Organic Chemistry
- Physical Chemistry
- Atomic and Molecular Physics and Spectroscopy