New Chiral Pyrimidino-Crown Ether Ligands.
BRIGHAM YOUNG UNIV PROVO UT DEPT OF CHEMISTRY
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Two new chiral macrocyclic ligands containing the pyrimidine subcyclic unit Figure 1 have been prepared. Chiral dimethyl-substituted pyrimidino-crown 1 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate 3 and chiral dimethyl-substituted tetraethylene glycol. Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate 4 with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 2. Starting 4-methoxy-5-methyl-2, 6-pyrimidinedimethanol 11 was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.
- Inorganic Chemistry
- Organic Chemistry
- Physical Chemistry
- Atomic and Molecular Physics and Spectroscopy