Accession Number:

ADA279323

Title:

Interpreting a Single Antistreptolysin O Test: A Comparison of the Upper Limit of Normal and Likelihood Ratio Methods

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT NO 3 CAIRO (EGYPT) DEPT OF MEDICAL ZOOLOGY

Report Date:

1993-01-01

Pagination or Media Count:

7.0

Abstract:

Single serologic tests may occasionally influence clinicians in making diagnoses. The antistreptolysin O ASO test is a frequently used tool for detecting recent Streptococcus pyogenes infection and is helpful in the diagnosis of diseases like rheumatic fever. Using data from a 1989 prospective study of 600 healthy male military recruits, in which 43 experienced S. pyogenes upper respiratory tract infection 2-dilution rise in ASO, this report compared two methods of interpreting a single ASO titer. Using the upper limit of normal 80 percentile method, recruits with an ASO titer of greater than 400 showed evidence of recent S. pyogenes infection. This method had a sensitivity and specificity of only 65.9 and 81.9 respectively. In contrast to the yes-no dichotomy of the upper limit of normal method, the likelihood ratio method statistics were ASO value specific, more consistent with clinical judgement, and better emphasized the caution clinicians must use in interpreting a single ASO test

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE