Accession Number:

ADA279195

Title:

Developmental Toxicity of OTTO Fuel II in the Rat and Rabbit

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1993-01-01

Pagination or Media Count:

7.0

Abstract:

OTTO Fuel II OFII is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time-mated Fischer-344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mgkgday. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mgkgday of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animals back at the rate of 0, 100, 316 and 1000 mgkgday. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mgkgday dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses faded to reveal significant evidence of fetal malformations. OTTO Fuel II, Teratology, Rat, Rabbit, Propylene Glycol Dinitrate PGDN

Subject Categories:

  • Toxicology
  • Torpedoes
  • Fuels

Distribution Statement:

APPROVED FOR PUBLIC RELEASE