Accession Number:

ADA278652

Title:

Malaria Vaccine Study Site in Irian Jaya, Indonesia: Plasmodium Falciparum Incidence Measurements and Epidemiologic Considerations in Sample Size Estimation

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Jones, Trevor R.
• Baird, J. K.
• Bangs, Michael J.
• Annis, Barry A.
• Basri, Hasan

Report Date:

1994-01-01

Pagination or Media Count:

7.0

Abstract:

Malaria epidemiologic and entomologic studies were performed during both the high transmission and low transmission seasons to characterize the Plasmodium falciparum malaria transmission at a proposed malaria vaccine trial size in Irian Jaya, Indonesia. The study population consisted of two subsets native Irianese men with lifelong exposure to malaria and transmigrants who arrived from a nonmalarious area 2.5 years before the start of the study. All subjects received a radical cure for malaria and were then monitored weekly by blood film. Both P. falciparum malaria attack rates and incidence densities were calculated transmigrants had a significantly higher rate P0.003 than the Irianese during the low transmission season study 20 weeks long but not during the high transmission season study 12-weeks long. Lack of exposure-induced immunity left the transmigrants at a minimum 17-25 greater relative risk of becoming parasitemic compared with the Irianese during the low transmission season study.

Descriptors:

• *MALARIA
• *PLASMODIUM FALCIPARUM
• *VACCINES
• REPRINTS
• SIZES(DIMENSIONS)
• PROTEINS
• RATES
• SPOROZOITES
• CELLS(BIOLOGY)
• IMMUNITY
• INFECTIOUS DISEASES
• ANTIBODIES
• EXPOSURE(PHYSIOLOGY)
• PARASITES

Subject Categories:

• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE