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Neostriatal Neuronal Activity and Behavior
Final rept. 1 Jun 1992-30 Sep 1993
WAKE FOREST UNIV WINSTON-SALEM NC DEPTOF PHYSIOLOGY AND PHARMACOLOGY
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The overall goal of the University Initiative project Neostriatal Neuronal Activity and Behavior was to establish a new technical approach for the study of ensembles of single neurons in CNS during tasks requiring sensory motor integration. An aim was to establish methodology for chronic implant of arrays of recording electrodes in rat neostriatum and other regions. Instrumentation was to be developed to allow amplification and spike sorting to be done for up to 64 concurrent spike trains. An acquisition system was to record the time events of spike trains, stimuli, and behavior events for up to four days continuously. An analysis capability was to provide a wide range of standard analysis procedures including histograms and rasters. A new approach for neuron ensemble analysis was to be developed to deal with statistical fluctuations of ensemble patterned activity across trials. Experimental studies were to study neuronal population activity during a series of tasks including tone and treadmill locomoting and a delayed matching-to-sample task with a spatial memory requirement. Computational simulation was to be done to explore short-term memory properties of the local circuitry between medium spiny neurons in neostriatum. Development of the experimental approach was the primary goal. Extended experimental analysis was secondary for this type of developmental project.
APPROVED FOR PUBLIC RELEASE