Variability of Serial Absolute and Percent CD4+ Lymphocyte Counts in Healthy Children Born to Human Immunodeficiency Virus 1-Infected Parents
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF PEDIATRICS
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The management of infants and children born to human immunodeficiency virus HIV-l-infected mothers is complicated by both the presence of maternal antibody during the first 18 months of life and the normal, physiologic decline of CD4 cell counts and percentage in infants 1 2 Because early diagnosis of HIV-1 infection in infants and children born to HIV-1-infected mothers is difficult, T cell subset analysis, particularly absolute CD4 lymphocyte number CD4 , has been used to guide decisions regarding the institution of Pneumocystis carinii pneumonia prophylaxis and antiretroviral therapy. 34 Although age-specific normal values for T cell phenotypes have been described recently, the power of CD4 to predict the risk for or the development of immunocompromised status is not well-defined except for the advent of P. carinii pneumonia in the first year of life.
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