Amino Acid Neurotransmitters and High Pressure Nervous Syndrome
NEW YORK STATE DEPT OF HEALTH ALBANY
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High pressure nervous syndrome HPNS occurs in humans and animals exposed to high atmospheric pressures such as those experienced during deep diving. The primary symptoms of HPNS, which are tremors and seizures, may result from excessive excitatory or inhibitory neurotransmission in the central nervous system. This project comprised two components. The first was a detailed study of the mechanisms by which excitatory and inhibitory transmitters are released from astroglial cells in vitro and the effects of high pressure on these processes. The second component was the analysis of amino acids specifically including glutamate, aspartate, taurine, and gamma-aminobutyric acid of perfusion fluids and tissue extracts received from the Hyperbaric Medicine Program Center, NMRI, Bethesda, MD.