Sensible Heat Loss After Systemic Anticholinergic Treatment
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
Pagination or Media Count:
Systemic atropine administration decreases eccrine sweat gland release via competitive inhibition at cholinergic receptors and augments skin blood flow by a yet unknown mechanism. Increased skin blood flow promotes auxiliary radiative and convective heat flux by 20-100 in both warm and cold environments. These studies showed that the systemic dose of atropine 2 mg, im was sufficient to block cholinergic sweat gland activity and core and skin temperatures were higher after atropine compared to control experiments. There was an enhanced skin blood flow thermosensitivity to esophageal temperature drive following atropine administration.
- Organic Chemistry