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Development of Carcinogenesis Bioassay Models: Response of Small Fish Species to Various Classes of Carcinogens
Final rept. 9 Mar 1988-8 Sep 1991
GULF COAST RESEARCH LAB OCEAN SPRINGS MS
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Studies were conducted related to the development of small fish carcinogenesis bioassay models using the medaka Oryzias latipes and the guppy Poecilia reticulata. The specific aim of the project was to identify certain classes of carcinogens that would induce neoplastic lesions in those model species. Bioassays were conducted on the following compounds the halogenated hydrocarbons 1,1,2,2-tetrachlorothane TeCE, chlorodibromethane CDBM, and vinylidene chloride VDC, the heavy metal cadmium Cd, the aromatic amines 2- acetylaminofluorene AAF and 4-aminobiphenyl ABP, the nitrogen-substituted polyaromatic hydrocarbon dibenzocarbazole DBC, the industrial product acrylonitrile AN and the pharmaceutical methapyrilene MP. Bioassays were conducted TeCE, CDBM, VDC, Cd, AAF, ABP, AN, and MP on medaka and guppy and DBC on medaka only. Mechanisms of ethylene dibromide metabolism were examined in medaka and of acetylaminofluorene in medaka and guppy. Other carcinogen bioassay factors such as the occurrence of background and rare carcinogen-induced tumors were examined in both species
APPROVED FOR PUBLIC RELEASE