Preclinical Toxicology Studies of New Drugs and Vaccines.
Annual rept. 15 Nov 92-14 Nov 93,
ILLINOIS UNIV AT CHICAGO CIRCLE
Pagination or Media Count:
During the reporting period, Thirteen Week Oral Toxicity Studies of WR6026 with a Thirteen Week Recovery Period in dogs and rats, In Vitro Mutagenicity Tests of HI-6 Dichloride and an Acute Oral and intraperitoneal Toxicity Study of WR242511 and WR269410 in mice were completed and study reports were submitted. Draft reports were submitted for Thirteen Week Oral Toxicity Studies of WR238605 with a Thirteen Week Recovery Period in both dogs and rats. WR242511 and WR269410 were studied in a Chromosome Aberrations in Chinese Hamster Ovary CHO Cells Assay, a SalmonellaMammalian-Microsome Plate Incorporation Mutagenicity Assay Ames Test, a L5178Y TK - Mouse Lymphoma Mutagenesis Assay, and a Two Week Oral Dose Range-Finding Toxicity Study in rats. Draft reports were submitted for these studies. Lastly, an Acute Oral and Intraperitoneal Toxicity Study of WR242511 and WR269410 in rats was completed, and a draft report was submitted. Toxicity, Rats, Dogs, HI-6 Dichloride, WR242511, WR269410, WR6026, RA I, V, II.
- Medicine and Medical Research