Accession Number:

ADA276544

Title:

Association of Protein S Deficiency with Thrombosis in a Kindred with Increased Levels of Plasminogen Activator Inhibitor-1

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Report Date:

1993-10-15

Pagination or Media Count:

9.0

Abstract:

The most common inherited abnormalities associated with familial venous thrombosis are deficiencies of protein S, protein C, and antithrombin III 1-3. All are inherited in an autosomal dominant manner and can result in venous thrombosis at young age. The most common of these three deficiencies is protein S, which circulates in a free from and in an inactive complex with C4b-binding protein. Only unbound or free protein S has functional activity as a cofactor for activated protein C in inhibiting factors Va and VIIIa 4. Thus, assessment of patients for protein S deficiency includes measurement of the level or activity of free protein S.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE