Accession Number:

ADA276531

Title:

Vaccine-Induced Enhancement of EIAV Replication and Disease

Descriptive Note:

Final rept. 15 Jun-31 Dec 1993

Corporate Author:

PITTSBURGH UNIV PA SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1994-01-14

Pagination or Media Count:

7.0

Abstract:

The purpose of this funding was to initiate the expansion of ongoing research in which the equine infectious anemia virus EIAVShetland pony animal lentivirus system is being used as a model for human AIDS vaccines with respect to the elucidation of the mechanisms of vaccine enhancement, the evaluation of in vitro enhancement assays as correlates of in vivo enhancement, and the development of vaccination strategies that minimize the potential for deleterious immune responses. The current funding was specifically provided as a supplement to expand isolation facilities for housing EIAV-infected ponies, for the purchase of additional ponies to be used in vaccine trials, and for the production and biochemical characterization of recombinant protein vaccine, rgp9O. All of these objectives have now been accomplished in anticipation of additional funding that will facilitate more detailed studies of vaccine-induced enhancement of EIAV replication and disease. AIDS Vaccines, Equine infectious anemia virus, Vaccine enhancement, Antibody dependent enhancement.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE