Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality
Annual rept. no. 2, 1 Feb 1993-31 Jan 1994
EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC
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The work has been proceeding as outlined in the proposal. At UNC- Chapel Hill, the main focus has been on studies in animals, including whole body scans in dogs after infusion of radiolabelled rehydrated canine platelets and assessment of multiple infusions of non-labelled rehydrated platelets. The attached subcontract report from Dr. Read and colleagues shows that the radiolabelled platelets were distributed in the dogs in a diffuse pattern when examined 4 hours after infusion. This is a good result, considering that a finding of localized accumulations of infused platelets might have indicated a tendency for spontaneous thrombus formation. The multiple infusion studies have not produced any evidence as yet of an immune reaction to rehydrated homologous platelets up to 7 infusions in same animal however, earlier experiments showed that it was necessary to change from bovine serum albumin in the preparation to canine albumin to avoid an immediate allergic reaction.
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