Accession Number:

ADA275483

Title:

Intravital Microscopic Evidence that Polylactide-Polyglycolide (PLGA) delays Neo-Osteogenesis and Neo-Angiogenesis in Healing Bone

Descriptive Note:

Corporate Author:

ARMY INST OF DENTAL RESEARCH WASHINGTON DC

Personal Author(s):

Report Date:

1993-01-01

Pagination or Media Count:

11.0

Abstract:

The bone chamber implant BCI has allowed monitoring a healing bone defect as well as the effect of an eroding implant on the healing process. The BCI is a useful tool and intravital microscopy a valuable technique for obtaining quantitative data chronicling osseous wound healing. The physiological parameters that form the initial data base documenting healing are neo- osteogenesis and neo-angiogenesis. This review compares and characterizes osseous wound healing in a BCI loaded with an erodible copolymer, PLGA polylactide-polyglycolide. To determine if a statistically significant deviation from normal healing had occurred, the results were compared with present and historical controls. In the BCI PLGA erosion was accompanied by a delay in the onset of neo-osteogenesis, as measured by trabecular opposition. Concurrently, neo-angiogenesis was both detained and retarded.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE