Accession Number:

ADA275482

Title:

Summary Report: Workshop on the Potential Risks of Antibody-Dependent Enhancement in Human HIV Vaccine Trials

Descriptive Note:

Journal article

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

• Mascola, John R.
• Mathieson, Bonnie J.
• Zack, Philip M.
• Walker, Mary C.
• Halstead, Scott B.
• Burke, Donald S.

Report Date:

1993-01-01

Pagination or Media Count:

11.0

Abstract:

In several human and animal viral diseases, suboptimal immunity to an infecting agent can cause as adverse or enhanced clinical expression of disease. This phenomenon of immune-mediated disease enhancement can occur on secondary exposure after natural infection, or after virus-specific immunization. In some diseasese.g. dengue, there is strong evidence that antibody-dependent enhancementADE of infection of monocytemacrophageMM cells is the pathophysiological mechanism for enhanced disease. In other viral infections, the pathophysiological mechanism is not understood and therefore the term immune-mediated disease enhancement is a more accurate description than ADE.

Descriptors:

• *AUGMENTATION
• *ANTIBODIES
• *HUMAN IMMUNODEFICIENCY VIRUSES
• REPRINTS
• CELLS
• INFECTIOUS DISEASES
• IMMUNIZATION
• MACROPHAGES
• RETROVIRUSES
• DENGUE
• VACCINES
• MONOCYTES
• IMMUNITY
• ANIMALS
• IN VITRO ANALYSIS
• SECONDARY

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE