Accession Number:

ADA275314

Title:

Two Antigenically Distinct Subtypes of Human Immunodeficiency Virus Type 1: Viral Genotype Predicts Neutralization Serotype

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Report Date:

1994-01-01

Pagination or Media Count:

8.0

Abstract:

At least five distinct genetic subtypesgenotypes of HIV 1 have been identified by DNA sequencing. Current vaccine candidates are based on virus strains from North America Europe that represent only one subtype. The extent to which distinct genotypes of HIV-1 correspond to antigenically distinguishable serotypes is largely unknown and may be critically important to vaccine design. Cross-neutralization studies were done with viruses plasma from 2 different genotypes. Based on neutralization susceptibility, 10 primary HIV-1 isolates from Thailand the U.S. were classified into one of two antigenic subtypes that correlated with viral genotype. The existence of serotypes of HIV-1 suggests that a broadly effective vaccine may have to include strains from multiple subtypes. Neutralization of these primary HIV-1 isolates differed substantially from results with laboratory strains. Future neutralization studies using primary isolates and multiple genotypes may be important-for assessment of HIV-1 antigenic diversity. HIV-1Human Immunodeficiency Virus Type 1, Neutralization studies, Antegenic subtype.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE